Spikeopathy: Spike Protein-Associated Pathobiology

A Series I: Definition and Scope

Foundational publication introducing the scope and framing of spike protein-associated pathobiology.

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Spikeopathy—Spike Protein–Associated Pathobiology: A Series I: Definition and Scope

Authors: Abdul Mannan Baig; Beate Jaeger; Brigitte König; Joachim Gerlach; Philip Mavberg; Sandy Rosko; Ivan Belynov; Usman Ali

This publication introduces the concept of Spikeopathy as a proposed framework for understanding persistent spike protein–associated pathology following SARS-CoV-2 exposure. The paper distinguishes spike-related pathobiology from broader post-viral syndromes by focusing on protein persistence, tissue distribution, and downstream inflammatory, vascular, neurological, and immunological consequences.

The framework is intended to support improved diagnostic thinking, biomarker-driven investigation, and translational research across post-infectious and post-vaccination chronic conditions.

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